Effects of visnagin on cyclic nucleotide phosphodiesterases and their role in its inhibitory effects on vascular smooth muscle contraction

被引：22

作者：

Duarte, J ^{[1
]}

Lugnier, C

Torres, AI

Perez-Vizcaino, F

Zarzuelo, A

Tamargo, U

机构：

[1] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain

[2] Univ Louis Pasteur Strasbourg 1, CNRS, URA 600, Pharmacol Cellulaire & Mol Lab, F-67401 Illkirch Graffenstaden, France

[3] Univ Complutense Madrid, Sch Med, Dept Pharmacol, E-28040 Madrid, Spain

来源：

GENERAL PHARMACOLOGY | 1999年 / 32卷 / 01期

关键词：

visnagin; aorta; rat; phosphodiesterases isoforms; Ammi visnaga; apiaceae;

D O I：

10.1016/S0306-3623(98)00083-4

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

1. Visnagin relaxed aortae previously contracted by noradrenaline. This effect was unalterated by endothelium removal and potentiated, at high concentrations, by the previous incubation with sodium nitroprusside. 2. Visnagin weakly inhibited the hydrolytic activity of the cyclic nucleotide phosphodiesterase (PDE) isozymes (PDE5, PDE4, PDE3, cyclic GMP activated PDE2 and PDE1). 3. The present results indicate an involvement of PDE inhibition in the relaxant effect of visnagin at high concentration (>5 x 10(-5) M). (C) 1998 Elsevier Science Inc.

引用

页码：71 / 74

页数：4

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