Allene-alkyne cross-coupling for stereoselective synthesis of substituted 1,4-dienes and cross-conjugated trienes

被引：24

作者：

Shimp, Heidi L. ^{[1
]}

Hare, Alissa ^{[1
]}

McLaughlin, Martin ^{[1
]}

Micalizio, Glenn C. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 16期

关键词：

D O I：

10.1016/j.tet.2008.02.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Titanium-mediated cross-coupling of allenic alcohols with alkynes has been investigated. Divergent reaction pathways were discovered that provide either stereodefined 1,4-dienes or substituted cross-conjugated trienes. In short, allene substitution plays a critical role in the determination of reaction pathway. (c) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：3437 / 3445

页数：9

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