Angiogenesis inhibitors as cancer therapy

被引：15

作者：

Eckhardt, SG ^{[1
]}

机构：

[1] Canc Therapy & Res Ctr, Inst Drug Dev, San Antonio, TX 78229 USA

来源：

HOSPITAL PRACTICE | 1999年 / 34卷 / 01期

关键词：

D O I：

10.3810/hp.1999.01.124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis inhibitors target a tumor's need to obtain nourishment from the host. In general, they are predicted to be chiefly cytostatic-that is, they stabilize tumors and perhaps prevent metastasis rather than being curative. Nevertheless, it remains conceivable that these agents may trigger tumor cell death. Novel evaluative strategies will be essential to define their potential roles.

引用

页码：63 / +

页数：11

共 10 条

[1] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [J].

Boehm, T ;

Folkman, J ;

Browder, T ;

OReilly, MS .

NATURE, 1997, 390 (6658) :404-407

[2]

Eckhardt SG, 1996, ANN ONCOL, V7, P491

[3] INTERFERON ALFA-2A THERAPY FOR LIFE-THREATENING HEMANGIOMAS OF INFANCY [J].

EZEKOWITZ, RAB ;

MULLIKEN, JB ;

FOLKMAN, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (22) :1456-1463

[4]

FOLKMAN J, 1995, NEW ENGL J MED, V333, P1753

[5]

FOLKMAN J, 1971, NEW ENGL J MED, V285, P82

[6] Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J].

Hanahan, D ;

Folkman, J .

CELL, 1996, 86 (03) :353-364

[7] ELEVATED LEVELS OF AN ANGIOGENIC PEPTIDE, BASIC FIBROBLAST GROWTH-FACTOR, IN THE URINE OF PATIENTS WITH A WIDE SPECTRUM OF CANCERS [J].

NGUYEN, M ;

WATANABE, H ;

BUDSON, AE ;

RICHIE, JP ;

HAYES, DF ;

FOLKMAN, J .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (05) :356-361

[8] ANGIOSTATIN - A NOVEL ANGIOGENESIS INHIBITOR THAT MEDIATES THE SUPPRESSION OF METASTASES BY A LEWIS LUNG-CARCINOMA [J].

OREILLY, MS ;

HOLMGREN, L ;

SHING, Y ;

CHEN, C ;

ROSENTHAL, RA ;

MOSES, M ;

LANE, WS ;

CAO, YH ;

SAGE, EH ;

FOLKMAN, J .

CELL, 1994, 79 (02) :315-328

[9] Endostatin: An endogenous inhibitor of angiogenesis and tumor growth [J].

OReilly, MS ;

Boehm, T ;

Shing, Y ;

Fukai, N ;

Vasios, G ;

Lane, WS ;

Flynn, E ;

Birkhead, JR ;

Olsen, BR ;

Folkman, J .

CELL, 1997, 88 (02) :277-285

[10]

Sills AK, 1998, CANCER RES, V58, P2784

← 1 →