Research around β2-glycoprotein I:: A major target for antiphospholipid antibodies

被引：23

作者：

Atsumi, T

Amengual, O

Yasuda, S

Matsuura, E

Koike, T

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Med 2, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Okayama Univ, Sch Med & Dent, Dept Cell Chem, Okayama, Japan

来源：

AUTOIMMUNITY | 2005年 / 38卷 / 05期

关键词：

nicked-beta; 2GPI; APS; fibrinolysis; thrombosis;

D O I：

10.1080/08916930500124312

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta 2-Glycoprotein I (beta 2GPI), a phospholipid-binding protein, is one of the major target antigens for antiphospholipid antibodies (aPL) found in patients with antiphospholipid syndrome (APS). Thrombophilic disorders in APS patients are strongly associated with aPL, and their pathogenic properties depend on the presence of beta 2GPI. Procoagulant cell stimulation by aPL, via beta 2GPI, is one of the most plausible mechanisms of thrombosis in APS, and p38 mitogen activated protein kinase (MAPK) pathway plays a crucial role in such activation. beta 2GPI is proteolytically cleaved in domain V by activated factor X or plasmin, leading to the generation of the nicked form of beta 2GPI. Recently, increasing attention is focused on the role of nicked-beta 2GPI as a regulator of extrinsic fibrinolysis pathway.

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页码：377 / 381

页数：5

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