Cholinergic stimulation of human microcitoma cell line H69

被引：17

作者：

Fucile, S

Napolitano, M

Mattei, E

机构：

[1] IST REGINA ELENA,CTR RIC,LAB BIOFIS,I-00158 ROME,ITALY

[2] CNR,IST TECNOL BIOMED,I-00161 ROME,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 230卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.5994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Experiments were addressed to investigate the mechanisms by which cholinergic stimulation is coupled to the enhancement of proliferation of small cell lung cancer cells H69. Muscarinic stimulation triggers the release of cytosolic Ca2+ and of inositol(1,4,5) trisphosphate with comparable time courses. The presence of alpha-bungarotoxin or the absence of Ca2+ in external medium suppresses enhancement of clonal growth induced by brief applications of nicotine. Here we suggest that Ca2+ mobilization represents a trigger for the enhancement of small cell lung cancer cell proliferation upon cholinergic stimulation. (C) 1997 Academic Press.

引用

收藏

页码：501 / 504

页数：4

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