Acute Chlamydia pneumoniae infection with heat shock protein 60-related response in patients with acute coronary syndrome

被引：23

作者：

Hoshida, S

Nishino, M

Tanouchi, J

Kishimoto, T

Yamada, Y

机构：

[1] Osaka Rosai Hosp, Div Cardiol, Sakai, Osaka, Japan

[2] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

来源：

ATHEROSCLEROSIS | 2005年 / 183卷 / 01期

关键词：

antibodies; atherosclerosis; inflammation;

D O I：

10.1016/j.atherosclerosis.2005.01.054

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence has suggested an association between Chlamydia pneumoniae infection and coronary atherosclerosis. A significant association has also been detected between heat shock protein (HSP) 60 antibody and the severity of coronary atherosclerosis. The aim of this study was to define the relationship between instability of ischemic heart disease (IHD) and serum levels of HSP60 and C pneumoniae antibodies. Blood samples for the measurement of serum antibody titers were obtained from 1131 patients with ischemic heart disease (65 9 years, male/female, 828/303) and 127 non-IHD controls with normal coronary arteries (64 9 years; male/female, 60/67) on the day of cardiac catheterization. The serum levels of anti-human HSP60 IgG antibody and anti-chlamydial IgM, but not IgG or IgA, antibody were significantly higher in ACS patients than in stable IHD patients or controls. These results suggest that acute C. pneumoniae infection with HSP60-related immunological responses may contribute to the pathophysiology of acute coronary syndromes. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：109 / 112

页数：4

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