An approach to multi-copy search in molecular replacement

被引:689
作者
Vagin, A [1 ]
Teplyakov, A
机构
[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England
[2] Ctr Adv Res Biotechnol, Rockville, MD 20850 USA
来源
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2000年 / 56卷
关键词
D O I
10.1107/S0907444900013780
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The molecular-replacement method has been extended to a simultaneous search for multiple copies of the macromolecule in the unit cell. The central point of this approach is the construction of a multi-copy search model from the properly oriented monomers using a special translation function. The multi-copy search method has been implemented in the program MOLREP and successfully tested using experimental data.
引用
收藏
页码:1622 / 1624
页数:3
相关论文
共 15 条
  • [1] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY
    BAILEY, S
    [J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 : 760 - 763
  • [2] Phased translation function
    Bentley, GA
    [J]. MACROMOLECULAR CRYSTALLOGRAPHY, PT A, 1997, 276 : 611 - 619
  • [3] Response surface methods for optimizing and improving reproducibility of crystal growth
    Carter, CW
    [J]. MACROMOLECULAR CRYSTALLOGRAPHY, PT A, 1997, 276 : 74 - 99
  • [4] CROWTHER RA, 1972, MOL REPLACEMENT METH, P173
  • [5] The solution structure of the bovine S100B protein dimer in the calcium-free state
    Kilby, PM
    VanEldik, LJ
    Roberts, GCK
    [J]. STRUCTURE, 1996, 4 (09) : 1041 - 1052
  • [6] Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor σF of Bacillus subtilis
    Kovacs, H
    Comfort, D
    Lord, M
    Campbell, ID
    Yudkin, MD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) : 5067 - 5071
  • [7] LEWIS R, 2000, COMMUNICATION
  • [8] MOROZ O, 2000, COMMUNICATION
  • [9] NAVAZA J, 2000, COMMUNICATION
  • [10] Rossmann M.G., 1972, The molecular replacement method