Activation of stem cells in hepatic diseases

被引：141

作者：

Bird, T. G. ^{[1
]}

Lorenzini, S. ^{[1
]}

Forbes, S. J. ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, MRC, Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

liver regeneration; liver cirrhosis; oval cells; stem cells; bone marrow;

D O I：

10.1007/s00441-007-0542-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The liver has enormous regenerative capacity. Following acute liver injury, hepatocyte division regenerates the parenchyma but, if this capacity is overwhelmed during massive or chronic liver injury, the intrinsic hepatic progenitor cells (HPCs) termed oval cells are activated. These HPCs are bipotential and can regenerate both biliary epithelia and hepatocytes. Multiple signalling pathways contribute to the complex mechanism controlling the behaviour of the HPCs. These signals are delivered primarily by the surrounding microenvironment. During liver disease, stem cells extrinsic to the liver are activated and bone-marrow-derived cells play a role in the generation of fibrosis during liver injury and its resolution. Here, we review our current understanding of the role of stem cells during liver disease and their mechanisms of activation.

引用

页码：283 / 300

页数：18

共 189 条

[1] Transplanted BM and BM side population cells contribute progeny to the lung and liver in irradiated mice [J].