Xenopus Zic family and its role in neural and neural crest development

被引：146

作者：

Nakata, K

Nagai, T

Aruga, J ^{[1
]}

Mikoshiba, K

机构：

[1] Inst Phys & Chem Res, Tsukuba Life Sci Ctr, Mol Neurobiol Lab, Ibaraki 3050074, Japan

[2] Inst Phys & Chem Res, Brain Sci Inst, Ibaraki 3050074, Japan

[3] Univ Tokyo, Inst Med Sci, Dept Mol Neurobiol, Minato Ku, Tokyo 1088639, Japan

[4] ERATO, Calciosignal Net Project, Meguro Ku, Tokyo 1530064, Japan

来源：

MECHANISMS OF DEVELOPMENT | 1998年 / 75卷 / 1-2期

基金：

日本学术振兴会;

关键词：

Zic; odd-paired; neural induction; neural crest; Xenopus; Zic family; Zic1; Zic2; Zic3; neural development; neural plate; neuroectoderm; Slug; Twist; melanocyte; somite; zinc finger protein;

D O I：

10.1016/S0925-4773(98)00073-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We characterized two new members of the Zic family, Xenopus Zic1 and Zic2. They are very similar to mouse Zic1 and Zic2 in the protein coding region including the zinc finger domain. In early gastrula, Zic1 expression was restricted to the prospective neural plate region whereas Zic2 was expressed widely in the ectoderm. We observed enhanced neural and neural crest-derived tissue formation in the Zic1 or Zic2 overexpressed embryos and neural and neural crest marker induction in the Zic1 or Zic2 overexpressed animal cap explants. Our findings suggest that Zic1 and Zic2 have essentially the same properties as Zi3 and that the Xenopus Zic family may act cooperatively in the initial phase of neural and neural crest development. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：43 / 51

页数：9

共 27 条

[1] Catching a Gli-mpse of Hedgehog [J].