Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats

被引：10

作者：

Chen, JL ^{[1
]}

Zhou, T

Chen, WX

Zhu, JS

Chen, NW

Zhang, MJ

Wu, YL

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Sixth Peoples Hosp, Dept Gastroenterol, Shanghai 200233, Peoples R China

[2] Shanghai Med Univ 2, Dept Nephrol, Ruijin Hosp, Shanghai 200025, Peoples R China

[3] Shanghai Med Univ 2, Anim Lab, Ruijin Hosp, Shanghai 200025, Peoples R China

[4] Shanghai Med Univ 2, Ruijin Hosp, Dept Gastroenterol, Shanghai 200025, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2003年 / 9卷 / 07期

关键词：

D O I：

10.3748/wjg.v9.i7.1563

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate the effect of tetra methylpyrazine on hepatic/renal ischemia and reperfusion injury in rats. METHODS: Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models. RESULTS: Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group. CONCLUSION: P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetra methylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.

引用

页码：1563 / 1566

页数：4

共 55 条

[1] Novel iron chelator in combination with a P-selectin antagonist prevents ischemia/reperfusion injury in a rat liver model [J].