Identifying global regulators in transcriptional regulatory networks in bacteria

被引：393

作者：

Martínez-Antonio, A ^{[1
]}

Collado-Vides, J ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Program Computat Genom, CIFN, Cuernavaca 62100, Morelos, Mexico

来源：

CURRENT OPINION IN MICROBIOLOGY | 2003年 / 6卷 / 05期

关键词：

D O I：

10.1016/j.mib.2003.09.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The machinery for cells to take decisions, when environmental conditions change, includes protein-DNA interactions defined by transcriptional factors and their targets around promoters. Properties of global regulators are revised attempting to reach diagnostic explicit criteria for their definition and eventual future computational identification. These include among others, the number of regulated genes, the number and type of co-regulators, the different sigma-classes of promoters and the number of transcriptional factors they regulate, the size of the evolutionary family they belong to, and the variety of conditions where they exert their control. As a consequence, global versus local regulation can be identified, as shown for Escherichia coli and eventually in other genomes.

引用

页码：482 / 489

页数：8

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