Iron catalyzed hydrodebromination of 2-aryl-1,1-dibromo-1-alkenes

被引：60

作者：

Fakhfakh, MA ^{[1
]}

Franck, X ^{[1
]}

Hocquemiller, R ^{[1
]}

Figadère, B ^{[1
]}

机构：

[1] Univ Paris Sud, Lab Pharmacognosie, CNRS BIOCIS, Fac Pharm, F-92296 Chatenay Malabry, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2001年 / 624卷 / 1-2期

关键词：

hydrodebromination; Grignard reagents; E vinyl bromides;

D O I：

10.1016/S0022-328X(00)00934-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Aryl- or 2-heteroaryl-1,1-dibromo-1-alkenes are reduced by Grignard reagents in a THF + NMP mixture in the presence of a catalytic amount of iron salts, to afford the corresponding E vinyl bromides. Further application to the one pot reduction-cross coupling reaction with Grignard reagents is highlighted. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：131 / 135

页数：5

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