Bimodal epidemic size distributions for near-critical SIR with vaccination

被引:12
作者
Gordillo, Luis F. [1 ]
Marion, Stephen A. [2 ]
Martin-Lof, Anders [3 ]
Greenwood, Priscilla E. [1 ]
机构
[1] Arizona State Univ, Dept Math & Stat, Math & Theoret Biol Inst, Tempe, AZ 85287 USA
[2] Univ British Columbia, Dept Hlth Care & Epidemiol, Vancouver, BC V6T 1W5, Canada
[3] Stockholm Univ, Dept Math, S-10691 Stockholm, Sweden
基金
美国国家科学基金会;
关键词
stochastic SIR; final size distribution; vaccination; bimodal distribution;
D O I
10.1007/s11538-007-9269-y
中图分类号
Q [生物科学];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
We introduce a recursive algorithm which enables the computation of the distribution of epidemic size in a stochastic SIR model for very large population sizes. In the important parameter region where the model is just slightly supercritical, the distribution of epidemic size is decidedly bimodal. We find close agreement between the distribution for large populations and the limiting case where the distribution is that of the time a Brownian motion hits a quadratic curve. The model includes the possibility of vaccination during the epidemic. The effects of the parameters, including vaccination level, on the form of the epidemic size distribution are explored.
引用
收藏
页码:589 / 602
页数:14
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