Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia

被引：11

作者：

Alfonso, Helman S. ^{[1
,2
,4
]}

Reid, Alison ^{[2
,5
]}

de Klerk, Nicholas H. ^{[2
,3
]}

Olsen, Nola ^{[2
]}

Mina, Robin ^{[2
]}

Ambrosini, Gina L. ^{[2
]}

Beilby, John ^{[6
]}

Berry, Geoffrey ^{[8
]}

Musk, Bill A. W. ^{[2
,7
]}

机构：

[1] Univ Western Australia, Sch Surg & Pathol, Perth, WA 6001, Australia

[2] QEII Med Ctr, Sch Populat Hlth, Nedlands, WA, Australia

[3] QEII Med Ctr, Dept Biostat & Genet Epidemiol, Telethon Inst Child Hlth Res, Nedlands, WA, Australia

[4] QEII Med Ctr, Western Australian Ctr Hlth & Ageing, Nedlands, WA, Australia

[5] QEII Med Ctr, Med Res Ctr, Nedlands, WA, Australia

[6] QEII Med Ctr, PathWest Lab Western Australia, Dept Mol Genet, Nedlands, WA, Australia

[7] Sir Charles Gairdner Hosp, Dept Resp Med, Perth, WA, Australia

[8] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2010年 / 19卷 / 05期

基金：

英国医学研究理事会;

关键词：

asbestos; crocidolite; mesothelioma; retinol; vitamin A; BETA-CAROTENE; VITAMIN-A; LUNG-CANCER; CARDIOVASCULAR-DISEASE; MORTALITY; SURVIVAL; MILLERS; MINERS;

D O I：

10.1097/CEJ.0b013e32833c1bcb

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Owing to the high rates of malignant mesothelioma in workers exposed to crocidolite earlier at Wittenoom and evidence of protection against cancer by vitamin A, a population-based cancer prevention programme providing retinol supplements (25 000 IU/day) was commenced in 1990. The former workers at Wittenoom known to be alive and living in Western Australia in June 1990 constitute the study population. The participants were classified into two groups: those who received supplemental retinol (intervention group) and those who received none (comparison group). The relative rate of mesothelioma for those receiving retinol was estimated using Cox regression, adjusting for cumulative asbestos exposure and age at first exposure to asbestos. Nine hundred and twenty-eight former Wittenoom workers received retinol at some stage of the programme, whereas 1471 workers never received retinol (comparison group). Those who received retinol were younger, had a greater exposure to asbestos and smoked less than the comparison group. There were 65 cases of mesothelioma in the retinol group and 88 in the comparison group. After adjustment, the hazard ratio was 0.99 (95% confidence interval = 0.70-1.41). This result did not alter when the participants who received only retinol once or those who received beta-carotene earlier were excluded from the analysis. In conclusion, this study provides little support for possible preventive effects of retinol against mesothelioma in workers exposed to blue asbestos. European Journal of Cancer Prevention 19: 355-359 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：355 / 359

页数：5

共 27 条

[1]

Plasma vitamin concentrations and incidence of mesothelioma and lung cancer in individuals exposed to crocidolite at Wittenoom, Western Australia [J].

Alfonso, Helman S. ;

Fritschi, Lin ;

de Klerk, Nicholas H. ;

Ambrosini, Gina L. ;

Beilby, John ;

Olsen, Nola ;

Musk, Arthur William .

EUROPEAN JOURNAL OF CANCER PREVENTION, 2006, 15 (04) :290-294

[2]

ARMSTRONG BK, 1988, BRIT J IND MED, V45, P5

[3]

Aydemir L, 1999, STAT MED, V18, P2123, DOI 10.1002/(SICI)1097-0258(19990830)18:16<2123::AID-SIM176>3.0.CO

[4]

2-4

[5]

Blomhoff R, 1994, Nutr Rev, V52, pS13, DOI 10.1111/j.1753-4887.1994.tb01382.x

[6]

de Klerk NH, 1998, INT J CANCER, V75, P362, DOI 10.1002/(SICI)1097-0215(19980130)75:3<362::AID-IJC6>3.0.CO

[7]

2-0

[8]

DEKLERK NH, 1989, BRIT J IND MED, V46, P529

[9]

DEKLERK NH, 1989, MED J AUSTRALIA, V151, P616

[10]

Environmental exposure to crocidolite and mesothelioma - Exposure-response relationships [J].

Hansen, J ;

de Klerk, NH ;

Musk, AW ;

Hobbs, MST .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (01) :69-75

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