Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22

被引：24

作者：

Zhong, W

Cui, B

Zhang, HS

Jiang, HS

Wei, SC

Bu, L

Zhao, GP

Hu, LD

Kong, XY ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Hlth Sci, Shanghai 20025, Peoples R China

[2] Shanghai Med Univ 2, Shanghai 20025, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Plant Physiol & Ecol, Shanghai, Peoples R China

[4] Shenyang Pharmaceut Univ, Shenyang, Peoples R China

[5] Sichuan Univ, Hauxi Hosp, Dept Dermatol, Chengdu 610064, Peoples R China

来源：

JOURNAL OF HUMAN GENETICS | 2003年 / 48卷 / 07期

关键词：

ichthyosis vulgaris (IV); skin disorder; linkage; lod score; chromosome; 1; epidermal differentiation complex (EDC);

D O I：

10.1007/s10038-003-0043-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ichthyosis vulgaris (IV) is an inherited scaling skin disorder with a prevalence estimated at 2.29% in China. The gene responsible for this disorder has not been elucidated. To find the disease gene, we ascertained two Chinese IV families. Linkage analysis identified an IV locus on chromosome 1q22 with a maximum two-point Lod score of 2.47 at D1S1653 (theta = 0.00). Haplotype analysis placed the critical region in a 7-cM interval defined by D1S1653 and D1S2675. These results provide the basis for further identifying the gene responsible for IV disorder.

引用

页码：390 / 392

页数：3

共 12 条

[1] Mapping of the associated phenotype of an absent granular layer in ichthyosis vulgaris to the epidermal differentiation complex on chromosome 1 [J].