Stress and the Gastrointestinal Tract -: III.: Stress-related alterations of gut motor function:: role of brain corticotropin-releasing factor receptors

被引：287

作者：

Taché, Y

Martinez, V

Million, M

Wang, LX

机构：

[1] Dept Vet Affairs Greater Los Angeles Hlthcare Syst, CURE Digest Dis Res Ctr, Los Angeles, CA 90073 USA

[2] Univ Calif Los Angeles, Dept Med, Div Digest Dis, Los Angeles, CA 90073 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2001年 / 280卷 / 02期

关键词：

astressin; corticotropin-releasing factor antagonist; gastric emptying; colonic transit; defecation; paraventricular nucleus of the hypothalamus; locus ceruleus;

D O I：

10.1152/ajpgi.2001.280.2.G173

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alterations of gastrointestinal (GI) motor function are part of the visceral responses to stress. Inhibition of gastric emptying and stimulation of colonic motor function are the commonly encountered patterns induced by various stressors. Activation of brain corticotropin-releasing factor (CRF) receptors mediates stress-related inhibition of upper GI and stimulation of lower GI motor function through interaction with different CRF receptor subtypes. CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome.

引用

收藏

页码：G173 / G177

页数：5

相关论文

共 34 条

[1] Neuroendocrine and autonomous mechanisms underlying thermoregulation in cold environment [J].

Arancibia, S ;

Rage, F ;

Astier, H ;

TapiaArancibia, L .

NEUROENDOCRINOLOGY, 1996, 64 (04) :257-267

[2] Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats [J].

Barquist, E ;

Bonaz, B ;

Martinez, V ;

Rivier, J ;

Zinner, MJ ;

Tache, Y .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1996, 270 (04) :R888-R894

[3] Level of chronic life stress predicts clinical outcome in irritable bowel syndrome [J].

Bennett, EJ ;

Tennant, CC ;

Piesse, C ;

Badcock, CA ;

Kellow, JE .

GUT, 1998, 43 (02) :256-261

[4] Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain [J].

Bonaz, B ;

Rivest, S .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (05) :R1438-R1449

[5]

Enck P., 1992, Neurogastroenterology Motility, V4, P83

[6] The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress [J].

Francis, DD ;

Caldji, C ;

Champagne, F ;

Plotsky, PM ;

Meaney, MJ .

BIOLOGICAL PSYCHIATRY, 1999, 46 (09) :1153-1166

[7] Glucagon-like peptide (GLP-1) is involved in the central modulation of fecal output in rats [J].

Gülpinar, MA ;

Bozkurt, A ;

Coskun, T ;

Ulusoy, NB ;

Yegen, BÇ .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (06) :G924-G929

[8] Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates [J].

Habib, KE ;

Weld, KP ;

Rice, KC ;

Pushkas, J ;

Champoux, M ;

Listwak, S ;

Webster, EL ;

Atkinson, AJ ;

Schulkin, J ;

Contoreggi, C ;

Chrousos, GP ;

McCann, SM ;

Suomi, SJ ;

Higley, JD ;

Gold, PW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :6079-6084

[9] Emotional behavior in the rat I Defecation and urination as measures of individual differences in emotionality [J].

Hall, CS .

JOURNAL OF COMPARATIVE PSYCHOLOGY, 1934, 18 (03) :385-403

[10] Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis [J].

Herman, JP ;

Cullinan, WE .

TRENDS IN NEUROSCIENCES, 1997, 20 (02) :78-84

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