Surface-active liposomes for targeted cancer therapy

被引：54

作者：

Sofou, Stavroula ^{[1
]}

机构：

[1] Polytech Univ, Lab Drug Delivery Syst, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY 11201 USA

来源：

NANOMEDICINE | 2007年 / 2卷 / 05期

关键词：

heat responsive liposomes; immunoliposomes; liposome cancer therapy; long circulating liposomes; PEGylated liposomes; pH-sensitive liposomes; responsive liposomes; targeted liposomes; temperature responsive liposomes;

D O I：

10.2217/17435889.2.5.711

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An overview of liposome-based drug-delivery carriers to cancer cells is presented. Properties related to interfacial interactions between liposomes and the biological milieu that determine the fate of liposomes in vivo are discussed. Original approaches to improve specificity for the target and to control the structural responsiveness of liposomes, depending on their immediate environment, with the aim of enhancing the delivered therapeutic doses, are summarized. This review is not exhaustive on research examples of liposomes as carriers for cancer therapy but, rather, aims to describe major directions of designs and strategies over recent years. The current therapeutic trends that exhibit increasingly higher complexity in structures and responses are also discussed.

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页码：711 / 724

页数：14

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