Total synthesis of (-)-episilvestrol and (-)-silvestrol

被引：52

作者：

El Sous, Mariana

Khoo, Mui Ling

Holloway, Georgina

Owen, David

Scammells, Peter J.

Rizzacasa, Mark A.

机构：

[1] Univ Melbourne, Sch Chem, Bio21 Inst, Melbourne, Vic 3010, Australia

[2] Cerylid Biosci, Richmond, Vic, Australia

[3] Monash Univ, Dept Med Chem, Victorian Coll Pharm, Parkville, Vic 3052, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 41期

关键词：

antitumor agents; cycloaddition; natural products; total synthesis;

D O I：

10.1002/anie.200702700

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sugar and spice... The total synthesis of the rare but potent anticancer natural product (-)-episilvestrol and its 5‴ epimer (-)-silvestrol was accompushed from D-glucose, naringenin, and methyl cinnamate (see scheme). The key steps of the sequence were inspired by the possible biogenesis of these compounds. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：7835 / 7838

页数：4

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