Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats

被引：165

作者：

Rahman, SM

Wang, YM

Yotsumoto, H

Cha, JY

Han, SY

Inoue, S

Yanagita, T ^{[1
]}

机构：

[1] Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan

[2] Natl Inst Hlth & Nutr, Div Geriatr Hlth & Nutr, Tokyo 162, Japan

来源：

NUTRITION | 2001年 / 17卷 / 05期

关键词：

conjugated linoleic acid; leptin; perirenal adipose tissue; brown adipose tissue; gastrocnemius muscle; carnitine-palmitoyltransferase activity; serum lipids;

D O I：

10.1016/S0899-9007(00)00584-0

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

We investigated the efficacy of a 4-wk supplementation of conjugated linoleic acid (CLA) as free fatty acid (FFA) or triacylglycerol (TG) on serum leptin concentration, body-fat accumulation, and mitochondrial P-oxidation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. A significant reduction of serum leptin concentration (42%) and a decrease in the wet weights of perirenal, epididymal, and omental/ visceral-adipose tissue in TG-CLA and FFA-CLA groups were found in comparison with the OLETF control group. Both forms of CLA supplementation produced a 5.2% decrease in body weight compared with the control even though food intake was similar in the OLETF groups. Moreover, both forms of CLA enhanced carnitine-palmitoyltransferase activity in brown adipose tissue, perirenal adipose tissue, red gastrocnemius muscle, and liver in comparison with the OLETF control group. Serum concentrations of non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA.

引用

页码：385 / 390

页数：6

共 48 条

[1]

Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat [J].