Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease

被引：35

作者：

Kauppinen, Tiina M.

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA

[2] Vet Affairs Med Ctr, San Francisco, CA 94121 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2007年 / 50卷 / 7-8期

关键词：

PARP-1; neuronal death; inflammation; DNA repair; neuroprotection;

D O I：

10.1016/j.neuint.2006.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the interest toward PARP-1 as a therapeutic target has peaked. This review introduces mechanism of PARP-1 activation, the role of PARP-1 in cell physiology and pathology, and discusses the potential of PARP-1 inhibition as a therapy in acute and chronic CNS diseases. (C) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：954 / 958

页数：5

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