The total synthesis of neoamphimedine

被引：27

作者：

LaBarbera, Daniel V. ^{[1
]}

Bugni, Tim S. ^{[1
]}

Ireland, Chris M. ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 22期

关键词：

D O I：

10.1021/jo7017813

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is the only member of more than one hundred pyridoacridines thus far to have this mechanism of action. Herein we report the first total synthesis of neoamphimedine.

引用

页码：8501 / 8505

页数：5

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