The multiple roles of estrogens and the enzyme aromatase

被引：128

作者：

Boon, Wah Chin ^{[1
,2
,3
,4
]}

Chow, Jenny D. Y. ^{[3
,4
]}

Simpson, Evan R. ^{[3
,5
]}

机构：

[1] Florey Neurosci Inst, Parkville, Vic, Australia

[2] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia

[3] Prince Henrys Inst, Clayton, Vic, Australia

[4] Monash Univ, Dept Anat & Dev Biol, Clayton, Vic, Australia

[5] Monash Univ, Dept Biochem, Clayton, Vic 3168, Australia

来源：

NEUROENDOCRINOLOGY: THE NORMAL NEUROENDOCRINE SYSTEM | 2010年 / 181卷

关键词：

aromatase; CYP19; estrogens; brain; neuroprotection; RECEPTOR-MESSENGER-RNA; CYTOCHROME-P450; GENE-EXPRESSION; ACID-METABOLIZING ENZYMES; DENDRITIC SPINE DENSITY; SIGNAL-REGULATED KINASE; VASCULAR SMOOTH-MUSCLE; ADIPOSE STROMAL CELLS; MEDIAL PREOPTIC AREA; MALE SEXUAL-BEHAVIOR; DEFICIENT ARKO MICE;

D O I：

10.1016/S0079-6123(08)81012-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Aromatase is the enzyme that catalyzes the last step of estrogen biosynthesis. It is expressed in many tissues such as the gonads, brain and adipose tissue. The regulation of the level and activity of aromatase determines the levels of estrogens that have endocrine, paracrine and autocrine effects on tissues. Estrogens play many roles in the body, regulating reproduction, metabolism and behavior. In the brain, cell survival and the activity of neurons are affected by estrogens and hence aromatase.

引用

页码：209 / 232

页数：24

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