Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma

被引：26

作者：

Casarsa, Claudia ^{[2
]}

Bassani, Niccole ^{[1
]}

Ambrogi, Federico ^{[1
]}

Zabucchi, Giuliano ^{[2
]}

Boracchi, Patrizia ^{[1
]}

Biganzoli, Elia ^{[1
]}

Coradini, Danila ^{[1
]}

机构：

[1] Univ Milan, Dept Work Med, Clin Lavoro L Devoto, Sect Med Stat & Biometry GA Maccacaro, I-20133 Milan, Italy

[2] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy

来源：

CANCER LETTERS | 2011年 / 302卷 / 02期

关键词：

Malignant pleural mesothelioma; Epithelial-to-mesenchymal transition; Cell polarity; Stemness features; E-CADHERIN; N-CADHERIN; ADHESION MOLECULES; GENE-EXPRESSION; POOR-PROGNOSIS; P21; EXPRESSION; CANCER; IDENTIFICATION; DROSOPHILA; MIGRATION;

D O I：

10.1016/j.canlet.2011.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and sternness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and sternness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues. MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and sternness. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：136 / 143

页数：8

共 61 条

[1]

Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

M-cam expression as marker of poor prognosis in epithelial ovarian cancer [J].

Aldovini, Daniela ;

Demichelis, Francesca ;

Doglioni, Claudio ;

Di Vizio, Dolores ;

Galligioni, Enzo ;

Brugnara, Sonia ;

Zeni, Bruna ;

Griso, Claudia ;

Pegoraro, Cristina ;

Zannoni, Marina ;

Gariboldi, Manuela ;

Balladore, Emanuela ;

Mezzanzanica, Delia ;

Canevari, Silvana ;

Barbareschi, Mattia .

INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (08) :1920-1926

[3]

[Anonymous], 2002, PRINCIPAL COMPONENTS

[4]

Polarity complex proteins [J].

Assemat, Emeline ;

Bazellieres, Elsa ;

Pallesi-Pocachard, Emilie ;

Le Bivic, Andre ;

Massey-Harroche, Dominique .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (03) :614-630

[5]

Identification of MCAM/CD146 as the Target Antigen of a Human Monoclonal Antibody that Recognizes Both Epithelioid and Sarcomatoid Types of Mesothelioma [J].

Bidlingmaier, Scott ;

He, Jiang ;

Wang, Yong ;

An, Feng ;

Feng, Jinjin ;

Barbone, Dario ;

Gao, Dongwei ;

Franc, Ben ;

Broaddus, V. Courtney ;

Liu, Bin .

CANCER RESEARCH, 2009, 69 (04) :1570-1577

[6]

β-catenin:: A pivot between cell adhesion and Wnt signalling [J].

Bienz, M .

CURRENT BIOLOGY, 2005, 15 (02) :R64-R67

[7]

Epithelial polarity and proliferation control:: links from the Drosophila neoplastic tumor suppressors [J].

Bilder, D .

GENES & DEVELOPMENT, 2004, 18 (16) :1909-1925

[8]

Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype [J].

Blanchard, Anne A. ;

Skliris, George P. ;

Watson, Peter H. ;

Murphy, Leigh C. ;

Penner, Carla ;

Tomes, Ladislav ;

Young, Tamara L. ;

Leygue, Etienne ;

Myal, Yvonne .

VIRCHOWS ARCHIV, 2009, 454 (06) :647-656

[9]

Notch signaling in development and cancer [J].

Bolos, Victoria ;

Grego-Bessa, Joaquin ;

de la Pompa, Jose Luis .

ENDOCRINE REVIEWS, 2007, 28 (03) :339-363

[10]

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila [J].

Brumby, AM ;

Richardson, HE .

EMBO JOURNAL, 2003, 22 (21) :5769-5779

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