Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia

被引：36

作者：

Lam, AGM

Soriano, MA

Monn, JA

Schoepp, DD

Lodge, D

McCulloch, J

机构：

[1] Univ Glasgow, Wellcome Surg Inst, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Glasgow, Hugh Fraser Neurosci Labs, Glasgow G61 1QH, Lanark, Scotland

[3] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

[4] F Hoffmann La Roche & Co Ltd, PRPN, CH-4070 Basel, Switzerland

来源：

NEUROSCIENCE LETTERS | 1998年 / 254卷 / 02期

基金：

英国惠康基金;

关键词：

metabotropic glutamate receptor; mGluR2; mGluR3; neuroprotection; MCA occlusion; focal ischaemia; LY354740;

D O I：

10.1016/S0304-3940(98)00651-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuroprotective effects of a systemically active, potent, group II selective metabotropic glutamate receptor agonist, LY354740, was assessed in the middle cerebral artery occlusion model of focal ischaemia in rats. LY354740 (0.3, 3.0 or 30.0 mg/kg) was administered subcutaneously (s.c.) 30 min prior to and 3 hours after the induction of ischaemia. Twenty four hours after the ischaemic insult, the brains were processed for the evaluation of infarct volumes. No significant reduction in infarct volumes were observed in treated animals at any of the doses investigated. These data provide no support for the view that group It metabotropic glutamate receptors have a major influence on ischaemic damage in this model. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：121 / 123

页数：3

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