Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study

被引：9

作者：

Cole, John W. ^{[1
,2
]}

Naj, Adam C. ^{[3
]}

O'Connell, Jeffrey R. ^{[4
,5
]}

Stine, Oscar C. ^{[4
,5
]}

Sorkin, John D. ^{[1
]}

Wozniak, Marcella A. ^{[1
,2
]}

Stern, Barney J. ^{[1
,2
]}

Yepes, Manuel ^{[6
]}

Lawrence, Daniel A. ^{[7
]}

Reinhart, Laurie J. ^{[5
]}

Strickland, Dudley K. ^{[8
]}

Mitchell, Braxton D. ^{[4
,5
]}

Kittner, Steven J. ^{[1
,2
]}

机构：

[1] Vet Affairs Med Ctr, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21201 USA

[4] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[6] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

[7] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[8] Univ Maryland, Sch Med, Ctr Vasc & Inflammatory Dis, Baltimore, MD 21201 USA

来源：

BMC NEUROLOGY | 2007年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2377-7-37

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Neuroserpin, primarily localized to CNS neurons, inhibits the adverse effects of tissue-type plasminogen activator (tPA) on the neurovascular unit and has neuroprotective effects in animal models of ischemic stroke. We sought to evaluate the association of neuroserpin polymorphisms with risk for ischemic stroke among young women. Methods: A population-based case-control study of stroke among women aged 15-49 identified 224 cases of first ischemic stroke (47.3% African-American) and 211 age-matched control subjects (43.1% African-American). Neuroserpin single nucleotide polymorphisms (SNPs) chosen through HapMap were genotyped in the study population and assessed for association with stroke. Results: Of the five SNPs analyzed, the A allele (frequency; Caucasian = 0.56, African-American = 0.42) of SNP rs6797312 located in intron 1 was associated with stroke in an age-adjusted dominant model (AA and AT vs. TT) among Caucasians (OR = 2.05, p = 0.023) but not African-Americans (OR = 0.71, p = 0.387). Models adjusting for other risk factors strengthened the association. Race-specific haplotype analyses, inclusive of SNP rs6797312, again demonstrated significant associations with stroke among Caucasians only. Conclusion: This study provides the first evidence that neuroserpin is associated with early-onset ischemic stroke among Caucasian women.

引用

页数：7

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