Effect of the MTHFRC677T variant on risk of venous thromboembolism:: Interaction with factor V Leiden and prothrombin (F2G20210A) mutations

被引：54

作者：

Brown, K ^{[1
]}

Luddington, R ^{[1
]}

Baglin, T ^{[1
]}

机构：

[1] Addenbrookes NHS Trust, Dept Haematol, Cambridge CB2 2QQ, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 103卷 / 01期

关键词：

thrombosis; methylenetetrahydrofolate reductase; factor V Leiden; prothrombin;

D O I：

10.1046/j.1365-2141.1998.00935.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Odds ratios for the MTHFRC677T variant were determined in a large case-control study of 558 unselected patients with venous thromboembolism and 500 control subjects. The odds ratios for MTHFRC677T heterozygosity and homozygosity were 1.07(95%CI 0.84-1.36) and 0.71 (95%CI 0.48-1.03). In patients with the factor V Leiden or the F2G20210A mutations there was no apparent increase in risk of venous thromboembolism due to the MTHFRC677T polymorphism. Thrombophilia testing should not include genotyping for the MTHFRC677T polymorphism.

引用

页码：42 / 44

页数：3

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