Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes

被引：38

作者：

Liu, Boyang ^{[1
]}

Garcia, Edwin A. ^{[1
]}

Korbonits, Marta ^{[1
]}

机构：

[1] Queen Mary Univ London, Dept Endocrinol, Barts & London Sch Med, London EC1M 6BQ, England

来源：

PEPTIDES | 2011年 / 32卷 / 11期

关键词：

Ghrelin; GHSR; Ghrelin receptor; Growth hormone secretagogue receptor; Ghrelin O-acyl transferase (GOAT); Genetic variability; Candidate gene studies; Genome-wide studies; GENOME-WIDE ASSOCIATION; BODY-MASS-INDEX; TYPE-2; DIABETES-MELLITUS; PREPROGHRELIN LEU72MET POLYMORPHISM; DENSITY-LIPOPROTEIN CHOLESTEROL; SINGLE NUCLEOTIDE POLYMORPHISM; NO SIGNIFICANT ASSOCIATION; EXTREMELY OBESE CHILDREN; FAMILY TRIOS ANALYSIS; HEALTHY NORMAL-WEIGHT;

D O I：

10.1016/j.peptides.2011.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ghrelin is a 28 amino acid peptide hormone that is produced both centrally and peripherally. Regulated by the ghrelin O-acyl transferase enzyme, ghrelin exerts its action through the growth hormone secretagogue receptor, and is implicated in a diverse range of physiological processes. These implications have placed the ghrelin signaling pathway at the center of a large number of candidate gene and genome-wide studies which aim to identify the genetic basis of human heterogeneity. In this review we summarize the available data on the genetic variability of ghrelin, its receptor and its regulatory enzyme, and their association with obesity, stature, type 2 diabetes, cardiovascular disease, eating disorders, and reward seeking behavior. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：2191 / 2207

页数：17

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