Synthesis of [18F]SU11248, a new potential PET tracer for imaging cancer tyrosine kinase

被引：39

作者：

Wang, JQ

Miller, KD

Sledge, GW

Zheng, QH ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 19期

关键词：

F-18]SU11248; synthesis; positron emission tomography; tracer; tyrosine kinase; cancer;

D O I：

10.1016/j.bmcl.2005.06.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-[F-18]fluoro-2-oxo-1, 2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, a new potential positron emission tomography tracer for imaging cancer tyrosine kinase, has been prepared by the nucleophilic substitution of the vitro-precursor N-[2- (diethylamino)ethyl]-5-[(Z)-(5-vitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide with (KF)-F-18/Kryptofix 2.2.2 followed by a simple chromatography methodology combined solid-phase extraction with high-performance liquid chromatography purification procedures in 15-25% radiochemical yields. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4380 / 4384

页数：5

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