14-3-3 proteins: key regulators of cell division, signalling and apoptosis

被引:471
作者
van Hemert, MJ
de Steensma, HY
van Heusden, GPH
机构
[1] Leiden Univ, Sect Yeast Genet, Inst Mol Plant Sci, NL-2333 AL Leiden, Netherlands
[2] Delft Univ Technol, Kluyver Lab Biotechnol, Delft, Netherlands
关键词
D O I
10.1002/bies.1134
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The 14-3-3 proteins constitute a family of conserved proteins present in all eukaryotic organisms so far investigated. These proteins have attracted interest because they are involved in important cellular processes such as signal transduction, cell-cycle control, apoptosis, stress response and malignant transformation and because at least 100 different binding partners for the 14- 3-3 proteins have been reported. Although the exact function of 14-3-3 proteins is still unknown, they are known to (1) act as adaptor molecules stimulating protein-protein interactions, (2) regulate the subcellular localisation of proteins and (3) activate or inhibit enzymes. In this review, we discuss the role of the 14-3-3 proteins in three cellular processes: cell cycle control, signal transduction and apoptosis. These processes are regulated by the 14-3-3 proteins at multiple steps. The 14-3-3 proteins have an overall inhibitory effect on cell cycle progression and apoptosis, whereas in signal transduction they may act as stimulatory or inhibitory factors. (C) 2001 John Wiley & Sons, Inc.
引用
收藏
页码:936 / 946
页数:11
相关论文
共 84 条
[1]   DIFFERENTIAL ACTIVATION OF PKC ISOZYMES BY 14-3-3-ZETA-PROTEIN [J].
ACS, P ;
SZALLASI, Z ;
KAZANIETZ, MG ;
BLUMBERG, PM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 216 (01) :103-109
[2]   14-3-3 and its possible role in co-ordinating multiple signalling pathways [J].
Aitken, A .
TRENDS IN CELL BIOLOGY, 1996, 6 (09) :341-347
[3]   Phosphoinositide-specific phospholipase C forms a complex with 14-3-3 proteins and is involved in expression of UV resistance in fission yeast [J].
Andoh, T ;
Kato, T ;
Matsui, Y ;
Toh-e, A .
MOLECULAR AND GENERAL GENETICS, 1998, 258 (1-2) :139-147
[4]   Binding of purified 14-3-3 ζ signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex [J].
Andrews, RK ;
Harris, SJ ;
McNally, T ;
Berndt, MC .
BIOCHEMISTRY, 1998, 37 (02) :638-647
[5]   INHIBITION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY BY ASSOCIATION WITH 14-3-3-PROTEINS IN T-CELLS [J].
BONNEFOYBERARD, N ;
LIU, YC ;
VONWILLEBRAND, M ;
SUNG, A ;
ELLY, C ;
MUSTELIN, T ;
YOSHIDA, H ;
ISHIZAKA, K ;
ALTMAN, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10142-10146
[6]   BCR AND RAF FORM A COMPLEX IN-VIVO VIA 14-3-3-PROTEINS [J].
BRASELMANN, S ;
MCCORMICK, F .
EMBO JOURNAL, 1995, 14 (19) :4839-4848
[7]   Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor [J].
Brunet, A ;
Bonni, A ;
Zigmond, MJ ;
Lin, MZ ;
Juo, P ;
Hu, LS ;
Anderson, MJ ;
Arden, KC ;
Blenis, J ;
Greenberg, ME .
CELL, 1999, 96 (06) :857-868
[8]   Human signaling protein 14-3-3ζ interacts with platelet glycoprotein Ib subunits Ibα and Ibβ [J].
Calverley, DC ;
Kavanagh, TJ ;
Roth, GJ .
BLOOD, 1998, 91 (04) :1295-1303
[9]   Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3 zeta [J].
Campbell, JK ;
Gurung, R ;
Romero, S ;
Speed, CJ ;
Andrews, RK ;
Berndt, MC ;
Mitchell, CA .
BIOCHEMISTRY, 1997, 36 (49) :15363-15370
[10]   14-3-3σ is required to prevent mitotic catastrophe after DNA damage [J].
Chan, TA ;
Hermeking, H ;
Lengauer, C ;
Kinzler, KW ;
Vogelstein, B .
NATURE, 1999, 401 (6753) :616-620