Application of systems biology for bioprocess development

被引：132

作者：

Park, Jin Hwan ^{[1
,2
]}

Lee, Sang Yup ^{[1
,2
,3
,4
]}

Kim, Tae Yong ^{[1
]}

Kim, Hyun Uk ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Inst BioCentury, Ctr Syst & Synthet Biotechnol,, Dept Chem & Biomol Engn,Program BK21,Metab & Biom, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Bioproc Engn Res Ctr, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, Bioinformat Res Ctr, Taejon 305701, South Korea

来源：

TRENDS IN BIOTECHNOLOGY | 2008年 / 26卷 / 08期

关键词：

D O I：

10.1016/j.tibtech.2008.05.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Random mutagenesis or genetic modification of an organism without consideration of its consequences to the entire system might cause unwanted changes in cellular metabolism. Systems metabolic engineering thus aims to develop strains by performing metabolic engineering within a systems biology framework, in which entire cellular networks are optimized and fermentation and downstream processes are considered at early stages. Thus, regulatory, metabolic and other cellular networks are engineered in an integrated manner. Here, we review the applications of systems biology for the development of strains and bioprocesses by means of several successful examples and, furthermore, discuss future prospects.

引用

收藏

页码：404 / 412

页数：9

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