New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities

被引：51

作者：

Fuchino, H

Koide, T

Takahashi, M

Sekita, S

Satake, M

机构：

[1] Natl Inst Hlth Sci, Div Pharmacognosy & Phytochem, Setagaya Ku, Tokyo 1588501, Japan

[2] Natl Inst Hlth Sci, Osaka Branch, Osaka 540, Japan

来源：

PLANTA MEDICA | 2001年 / 67卷 / 07期

关键词：

sesquiterpenes; Elephantopus mollis; Compositae; leishmaniasis; Leishmania major;

D O I：

10.1055/s-2001-17349

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The leishmanicidal compounds isolated from whole plants of Elephantopus mollis H.B.K. were identified as follows. Three new sesquiterpenoid lactones, 2,5-epoxy-2 beta -hydroxy-8 alpha-(2-methylpropenoyloxy)-4(15),10(14),11(13)-germacratrien-1 2,6 alpha -olide, (4 betaH)-8 alpha-(2-methylpropenoyloxy)-2-oxo-1(5),10(14), 11(13)-guaiatrien-12,6 alpha -olide and (4 betaH)-5 alpha -hydroxy-8 alpha-(2-methylpropenoyloxy)-1(10),11 (13)-guaiadiene-12,6 alpha -olide, were isolated from Peruvian and Brazilian collections together with four known sesquiterpenoids, molephantin, elephantopin, isoelephantopin and 2-deethoxy-2 beta -methoxyphantomolin. They exhibited potent in vitro leishmanicidal activities against Leishmania major. The alpha -methylene-gamma -butyrolactone moiety was found to be essential to the potent leishmanicidal effect observed.

引用

页码：647 / 653

页数：7

共 20 条

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