Design of engineered vaccines for systemic and mucosal immunity to HIV

被引：4

作者：

Berzofsky, JA ^{[1
]}

机构：

[1] NCI, Mol Immunogenet & Vaccine Res Sect, Metab Branch, NIH, Bethesda, MD 20892 USA

来源：

PATHOLOGIE BIOLOGIE | 2001年 / 49卷 / 06期

关键词：

HIV; mucosal immunity; peptides; T lymphocytes; vaccine;

D O I：

10.1016/S0369-8114(01)00167-5

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

To design vaccines for viruses such as HIV that do not elicit sufficient protective immunity, we first constructed cluster vaccines containing T helper, CTL and neutralizing antibody epitopes. For second generation vaccines, we increased responses by enhancing binding to Major Histocompatibility molecules or by incorporating cytokines. We found that high avidity CTL induce better viral clearance. We also induced anti-HIV mucosal T cell immunity by intrarectal administration. Such approaches may improve classic attenuated or killed pathogen vaccines. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：466 / 467

页数：2