Acquisition of host plasmin activity by the swine pathogen Streptococcus suis serotype 2

被引：37

作者：

Jobin, MC

Brassard, J

Quessy, S

Gottschalk, M

Grenier, D ^{[1
]}

机构：

[1] Univ Laval, Grp Rech Ecol Buccale, Fac Med Dent, Quebec City, PQ G1K 7P4, Canada

[2] Univ Montreal, Fac Med Vet, Grp Rech Malad Infect Porc, St Hyacinthe, PQ J2S 7C6, Canada

[3] Univ Montreal, Fac Med Vet, Canadian Res Network Bacterial Pathogens Swine, Nat Sci & Engn Res Council Canada, St Hyacinthe, PQ J2S 7C6, Canada

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 01期

关键词：

D O I：

10.1128/IAI.72.1.606-610.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, the plasminogen-binding activity of Streptococcus suis serotype 2 was investigated. Bound human plasminogen was activated by purified streptokinase, urokinase, or Streptococcus dysgalactiae subsp. equisimilis culture supernatant. Both human and porcine plasminogen were bound by S. suis. Binding was inhibited by E-aminocaproic acid, and the plasminogen receptor was heat and sodium dodecyl sulfate resistant. One of the receptors was identified as glyceraldehyde-3-phosphate dehydrogenase. S. suis-associated plasmin activity was capable of activating free plasminogen, which in turn could contribute to degradation of fibronectin. This is the first report on the plasminogen-binding activity of S. suis. Further studies may reveal a contribution of this activity to the virulence of S. suis.

引用

页码：606 / 610

页数：5

共 29 条

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