Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B

被引：80

作者：

Gooden, David M. ^{[1
]}

Schmidt, Dawn M. Z. ^{[1
]}

Pollock, Julie A. ^{[1
]}

Kabadi, Ami M. ^{[1
]}

McCafferty, Dewey G. ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 10期

关键词：

lysine-specific histone demethylase; LSD1; trans-2-cycloproylamine; parnate; tranylcypromine; monoamine oxidase; inhibitor;

D O I：

10.1016/j.bmcl.2008.01.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B. (c) 2008 Elsevier Ltd. All rights reserved.

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页码：3047 / 3051

页数：5

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