Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice

被引：259

作者：

Troy, Stephanie ^{[2
]}

Soty, Maud ^{[1
,3
,4
]}

Ribeiro, Lara ^{[2
]}

Laval, Laure ^{[1
,3
,4
]}

Migrenne, Stephanie ^{[5
]}

Fioramonti, Xavier ^{[5
]}

Pillot, Bruno ^{[1
,3
,4
]}

Fauveau, Veronique ^{[6
]}

Aubert, Roberte ^{[2
]}

Viollet, Benoit ^{[7
,8
]}

Foretz, Marc ^{[7
,8
]}

Leclerc, Jocelyne ^{[7
,8
]}

Duchampt, Adeline ^{[1
,3
,4
]}

Zitoun, Carine ^{[1
,3
,4
]}

Thorens, Bernard ^{[9
,10
]}

Magnan, Christophe ^{[5
]}

Mithieux, Gilles ^{[1
,3
,4
]}

Andreelli, Fabrizio ^{[2
,11
]}

机构：

[1] Fac Med Alexis Carrel, INSERM, U855, F-69372 Lyon, France

[2] Univ Paris 07, Fac Med Xavier Bichat, INSERM, U695, F-75870 Paris, France

[3] Univ Lyon, F-69008 Lyon, France

[4] Univ Lyon 1, F-69622 Villeurbanne, France

[5] Univ Paris 07, CNRS, U7059, F-75251 Paris, France

[6] Fac Med Cochin, IFR Alfred JOST, Inst Cochin, F-75014 Paris, France

[7] Univ Paris 05, CNRS, Inst Cochin, UMR 8104, Paris, France

[8] INSERM, U567, Paris, France

[9] Univ Lausanne, Inst Physiol, Lausanne, Switzerland

[10] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland

[11] CHU Bichat Claude Bernard, AP HP, Serv Diabet Endocrinol Nutr, F-75877 Paris, France

来源：

CELL METABOLISM | 2008年 / 8卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2008.08.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 diabetes mellitus (T2DM). We per-formed gastric lap-band (GLB) and entero-gastro anastomosis (EGA) procedures in C57BI6 mice that were fed a high-fat diet. The EGA procedure specifically reduced food intake and increased insulin sensitivity as measured by endogenous glucose production. Intestinal gluconeogenesis increased after the EGA procedure, but not after gastric banding. All EGA effects were abolished in GLUT-2 knockout mice and in mice with portal vein denervation. We thus provide mechanistic evidence that the beneficial effects of the EGA procedure on food intake and glucose homeostasis involve intestinal gluconeogenesis and its detection via a GLUT-2 and hepatoportal sensor pathway.

引用

页码：201 / 211

页数：11

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