Coupling reactions of aryl bromides with 1-alkynols catalysed by a tetraphosphine/palladium catalyst

被引：29

作者：

Feuerstein, M ^{[1
]}

Doucet, H ^{[1
]}

Santelli, M ^{[1
]}

机构：

[1] Fac Sci & Tech St Jerome, CNRS, Synth Organ Lab, F-13397 Marseille 20, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 08期

关键词：

palladium; catalysis; Sonogashira reaction; alkynol; aryl bromide;

D O I：

10.1016/j.tetlet.2003.12.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

cis. cis, cis-1, 2, 3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H5)](2) system catalyses efficiently the coupling reactions of aryl halides with a variety of alkynols such as propargy] alcohol, but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol. The catalyst can be used at lowloading. Higher reaction rates were observed in the presence of but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol than with propargy] alcohol. The protection of the alcohol functions as an ether or a silyloxy group led generally to similar or better results than the reactions performed with the unprotected alcohols. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1603 / 1606

页数：4

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