Mecamylamine-precipitated nicotine-withdrawal aversion in rats

被引：74

作者：

Suzuki, T

Ise, Y

Tsuda, M

Maeda, J

Misawa, M

机构：

[1] Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo 142, 2-4-41 Ebara, Shinagawa-ku

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 314卷 / 03期

关键词：

nicotine; mecamylamine; conditioned place preference paradigm; place aversion; physical dependence;

D O I：

10.1016/S0014-2999(96)00723-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated withdrawal aversion in rats chronically treated with nicotine may result from physical dependence on nicotine, and may be useful for studying the physical dependence on nicotine.

引用

页码：281 / 284

页数：4

共 15 条

[1] SITES OF ACTION OF ONDANSETRON TO INHIBIT WITHDRAWAL FROM DRUGS OF ABUSE [J].