Interactions of amphiphilic calix[4]arene-based Solid Lipid Nanoparticles with bovine serum albumin

被引：74

作者：

Gualbert, J ^{[1
]}

Shahgaldian, P ^{[1
]}

Coleman, AW ^{[1
]}

机构：

[1] CNRS, UMR 5086, Inst Biol & Chim Prot, F-69367 Lyon, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2003年 / 257卷 / 1-2期

关键词：

Solid Lipid Nanoparticles; calixarene; bovine serum albumin (BSA); Photon Correlation Spectroscopy (PCS); Atomic Force Microscopy (AFM);

D O I：

10.1016/S0378-5173(03)00138-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction of Solid Lipid Nanoparticles (SLN) based on amphiphilic calix[4]arene with one of the major circulatory protein, serum albumin, has been investigated by Photon Correlation Spectroscopy (PCS) and Atomic Force Microscopy (AFM). The carrier systems have shown the ability to interact with bovine serum albumin (BSA), which forms a capping layer up to 17 nm in depth. AFM imaging revealed that the SLNs are protected by this layer against flattening on surfaces. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：69 / 73

页数：5

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