Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis

被引：78

作者：

Hung, Tran Manh

Na, MinKyun

Min, Byung Sun

Ngoc, Tran Minh

Lee, IkSoo

Zhang, XinFeng

Bae, KiHwan ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

[3] Catholic Univ, Coll Pharm, Gyongsan 712702, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2007年 / 30卷 / 06期

关键词：

Schizandra chinensis; acetylcholinesterase (AChE); Alzheimer's disease; gomisin; schisandrin; wuweizisu;

D O I：

10.1007/BF02977628

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A (13), entirely inhibited AChE in dose dependent manners, with IC50 values of 6.71 +/- 0.53, 6.55 +/- 0.31, 7.84 +/- 0.62, 12.57 +/- 1.07 and 13.28 +/- 1.68 mu M, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.

引用

页码：685 / 690

页数：6

共 38 条

[1]

Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase activity by imidazo[2,1-b]thiazole derivatives [J].