Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli

被引：952

作者：

Shahverdi, Ahmad R.

Fakhimi, Ali

Shahverdi, Hamid R.

Minaian, Sara

机构：

[1] Med Sci Univ Tehran, Fac Pharm, Dept Pharmaceut Biotechnol, Tehran, Iran

[2] Med Sci Univ Tehran, Fac Pharm, Med Nanotechnol Res Ctr, Tehran, Iran

[3] Tarbiat Modares Univ, Fac Engn, Dept Mat Sci, Tehran, Iran

[4] Azad Univ Sci & Res Units, Div Microbiol, Tehran, Iran

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2007年 / 3卷 / 02期

关键词：

antibiotics resistance; Klebsiella pneumoniae; silver nanoparticles; synthesis;

D O I：

10.1016/j.nano.2007.02.001

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Silver nanoparticles (Ag-NPs) have been known to have inhibitory and bactericidal effects. Resistance to antimicrobial agents by pathogenic bacteria has emerged in recent years and is a major health problem. The combination effects of Ag-NPs with the antibacterial activity of antibiotics have not been studied. Here, we report on the synthesis of metallic nanoparticles of silver using a reduction of aqueous Ag+ ion with the culture supernatants of Klebsiella pneumoniae. Also in this article these nanoparticles are evaluated for their part in increasing the antimicrobial activities of various antibiotics against Staphylococcus aureus and Escherichia coli. The antibacterial activities of penicillin G, amoxicillin, erythromycin, clindamycin, and vancomycin were increased in the presence of Ag-NPs against both test strains. The highest enhancing effects were observed for vancomycin, amoxicillin, and penicillin G against S. aureus. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：168 / 171

页数：4

共 16 条

[1] Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction [J].