Coffee and endothelial function: a battle between caffeine and antioxidants?

被引:21
作者
Buscemi, S. [1 ]
Batsis, J. A. [2 ]
Arcoleo, G. [3 ]
Verga, S. [1 ]
机构
[1] Univ Palermo, Fac Med, Dipartimento Med Interna Malattie Cardiovasc & Ne, Palermo, Italy
[2] Dartmouth Hitchcock Med Ctr, Gen Internal Med Sect, Lebanon, NH 03766 USA
[3] Univ Palermo, Dept Engn & Technol Agr & Forestry, Palermo, Italy
关键词
coffee; antioxidants; caffeine; FMD; CAPACITY;
D O I
10.1038/ejcn.2010.137
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Although coffee is largely consumed by adults in Western countries, controversy exists about its impact on the cardiovascular system. We recently demonstrated that caffeinated and decaffeinated espresso coffee have different acute effects on endothelial function in healthy subjects, measured using flow-mediated dilation (FMD) of the brachial artery. In this study, we measured the anti-oxidant capacity of two coffee substances in terms of free stable radical 2,2-diphenyl-1-picryl-hydrazyl 50% inhibition (I-50 DPPH). The caffeinated coffee had a slightly higher anti-oxidant capacity than decaffeinated espresso coffee (I-50 DPPH: 1.13 +/- 0.02 vs 1.30 +/- 0.03 mu l; P<0.001). We suggest that the unfavourable effects observed after caffeinated coffee ingestion are due to caffeine and that the antioxidant activity is responsible for the increased FMD observed after decaffeinated coffee ingestion. Further clinical and epidemiological studies are needed to understand the chronic effects of coffee consumption on health. European Journal of Clinical Nutrition (2010) 64, 1242-1243; doi:10.1038/ejcn.2010.137; published online 28 July 2010
引用
收藏
页码:1242 / 1243
页数:2
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