Area postrema glutamate receptors mediate respiratory and gastric responses in the rabbit

被引：22

作者：

Bongianni, F ^{[1
]}

Mutolo, D ^{[1
]}

Carfi, M ^{[1
]}

Pantaleo, T ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Sci Fisiol, I-50134 Florence, Italy

来源：

NEUROREPORT | 1998年 / 9卷 / 09期

关键词：

area postrema; brain stem; excitatory amino acid receptors; gastric motility; rabbit; respiration; vagus nerve;

D O I：

10.1097/00001756-199806220-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE role of NMDA and non-NMDA receptors of the area postrema (AP) in the control of respiration and gastric motility was investigated in anaesthetized rabbits using microinjections (10-20 nl) of specific agonists or antagonists. NMDA (20 mM) or AMPA (10 mM) caused excitatory effects on respiration and gastric relaxation. Selective blockade of NMDA or non-NMDA receptors, respectively with D(-)-2-amino-5-phosphonopentanoic acid (D-AP5; 10 mM) and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione (NBQX; 5 mM), decreased respiratory frequency and increased gastric tone. Both these effects were more marked following non-NMDA receptor blockade and were prevented by vagotomy. These findings show that NMDA and non-NMDA receptors are present on AP neurones and have a role in the tonic control of respiration and gastric motility. (C) 1998 Rapid Science Ltd.

引用

页码：2057 / 2062

页数：6

共 23 条

[1] VAGAL RELAXATION OF STOMACH INDUCED BY APOMORPHINE IN CAT [J].