Conodiparines A-D, new bisindoles from Tabernaemontana.: Reversal of vincristine-resistance with cultured cells

被引：50

作者：

Kam, TS ^{[1
]}

Sim, KM

Koyano, T

Toyoshima, M

Hayashi, M

Komiyama, K

机构：

[1] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Temko Corp, Nakano Ku, Tokyo 164, Japan

[3] Kitasato Inst, Minato Ku, Tokyo 108, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00294-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Four new bisindoles of the vobasine-iboga type, conodiparines A-D were obtained from Tabernaemontana corymbosa which showed appreciable activity in reversing resistance in vincristine-resistant KB cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1693 / 1696

页数：4

相关论文

共 12 条

[1]

BUDZIKIEWICZ H, 1963, B SOC CHIM FR, P1899

[2]

NEW DIMERIC INDOLE ALKALOIDS FROM ERVATAMIA-HAINANENSIS [J].

FENG, XZ ;

LIU, G ;

KAN, C ;

POTIER, P ;

KAN, SK .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (05) :928-933

[3]

LUNDURINE-A, LUNDURINE-B AND LUNDURINE-C, NEW INDOLE ALKALOIDS NOVEL CARBON SKELETON CONTAINING A CYCLOPROPYL MOIETY [J].

KAM, TS ;

YOGANATHAN, K ;

CHUAH, CH .

TETRAHEDRON LETTERS, 1995, 36 (05) :759-762

[4]

Tenuisines A, B and C, novel bisindoles with C-2 symmetry from Kopsia tenuis [J].

Kam, TS ;

Yoganathan, K ;

Li, HY .

TETRAHEDRON LETTERS, 1996, 37 (48) :8811-8814

[5]

Tenuisines A-C and tenuiphylline, novel bisindoles from Kopsia tenuis [J].

Kam, TS ;

Yoganathan, K ;

Li, HY ;

Harada, N .

TETRAHEDRON, 1997, 53 (37) :12661-12670

[6]

Pauciflorines A and B, novel melanin biosynthesis inhibitors from Kopsia [J].

Kam, TS ;

Yoganathan, K ;

Koyano, T ;

Komiyama, K .

TETRAHEDRON LETTERS, 1996, 37 (32) :5765-5768

[7]

Oxo-derivatives of kopsine- and rhazinilam-type alkaloids from a north Borneo Kopsia [J].

Kam, TS ;

Subramaniam, G .

NATURAL PRODUCT LETTERS, 1998, 11 (02) :131-136

[8]

KOPSIA-PAUCIFLORA .1. STRUCTURE AND ABSOLUTE-CONFIGURATION OF NEW ASPIDOSPERMANE-EBURNANE-TYPE DIMERIC INDOLIC ALKALOIDS OF THE PLEIOMUTINE-KOPSOFFINE SERIES [J].

KANFAN, C ;

SEVENET, T ;

HUSSON, HP ;

CHAN, KC .

JOURNAL OF NATURAL PRODUCTS, 1985, 48 (01) :124-127

[9]

KOHNO K, 1988, JPN J CANCER RES, V79, P1283

[10]

TAKAYAMA H, 1994, CHEM PHARM BULL, V42, P280, DOI 10.1248/cpb.42.280