The cancer stem cell: premises, promises and challenges

被引：1629

作者：

Clevers, Hans ^{[1
,2
]}

机构：

[1] Royal Netherlands Acad Arts & Sci, Hubrecht Inst, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Utrecht, Netherlands

来源：

NATURE MEDICINE | 2011年 / 17卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; TUMOR-INITIATING CELLS; BREAST-CANCER; LYMPHOBLASTIC-LEUKEMIA; PANCREATIC-CANCER; MELANOMA-CELLS; MOUSE MODEL; GENOMIC INSTABILITY; CLONAL EVOLUTION; SCID MICE;

D O I：

10.1038/nm.2304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Over the last decade, the notion that tumors are maintained by their own stem cells, the so-called cancer stem cells, has created great excitement in the research community. This review attempts to summarize the underlying concepts of this notion, to distinguish hard facts from beliefs and to define the future challenges of the field.

引用

收藏

页码：313 / 319

页数：7

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