Perioperative melatonin use

被引：17

作者：

Jarratt, J. ^{[1
]}

机构：

[1] Christchurch Hosp, Dept Anaesthet, Christchurch, New Zealand

来源：

ANAESTHESIA AND INTENSIVE CARE | 2011年 / 39卷 / 02期

关键词：

melatonin; anaesthetic; premedication; ISCHEMIA-REPERFUSION INJURY; SLEEP-WAKE CYCLE; SPINAL-CORD-INJURY; RAT PINEAL-GLAND; EXOGENOUS MELATONIN; DOUBLE-BLIND; ORAL MELATONIN; CIRCADIAN-RHYTHM; DOSE-RESPONSE; ISCHEMIA/REPERFUSION INJURY;

D O I：

10.1177/0310057X1103900205

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Melatonin is a substance chiefly produced by the pineal gland and has a key role in the sleep-wake cycle. It also has an important antioxidant role. Exogenous melatonin has a short half-life and is available in a range of preparations. Newer analogues targeted for the recently discovered melatonin MT1 and MT2 receptors have also been developed. Exogenous melatonin is used as a resynchronisation agent in jet lag and for other sleep disturbances. Perioperatively, melatonin has been used as a premedicant, sedative and analgesic. It decreases paediatric emergence delirium. The antioxidant properties of melatonin are being investigated for use in sepsis and reperfusion injuries. It would appear that patients on melatonin supplements should continue taking them perioperatively because there may be benefits. Melatonin and its analogues will be increasingly encountered in the pert operative setting.

引用

页码：171 / 181

页数：11

共 137 条

[1]

Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance [J].

Acil, M ;

Basgul, E ;

Celiker, V ;

Karagöz, AH ;

Demir, B ;

Aypar, U .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2004, 21 (07) :553-557

[2]

ACUNA CD, 2002, CURR TOP MED CHEM, V2, P133, DOI DOI 10.2174/1568026023394344]

[3]

PLASMA-CONCENTRATIONS OF MELATONIN IN MAN FOLLOWING ORAL ABSORPTION OF DIFFERENT PREPARATIONS [J].

ALDHOUS, M ;

FRANEY, C ;

WRIGHT, J ;

ARENDT, J .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 19 (04) :517-521

[4]

Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors [J].

Ambriz-Tututi, Monica ;

Granados-Soto, Vinicio .

PAIN, 2007, 132 (03) :273-280

[5]

Melatonin as a chronobiotic [J].

Arendt, J ;

Skene, DJ .

SLEEP MEDICINE REVIEWS, 2005, 9 (01) :25-39

[6]

Arendt J, 1998, REV REPROD, V3, P13, DOI 10.1530/revreprod/3.1.13

[7]

The relation between the clinical subtypes of delirium and the urinary level of 6-SMT [J].

Balan, S ;

Leibovitz, A ;

Zila, SO ;

Ruth, M ;

Chana, W ;

Yassica, B ;

Rahel, B ;

Richard, G ;

Neumann, E ;

Blagman, B ;

Habot, B .

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2003, 15 (03) :363-366

[8]

Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial [J].

Bourne, Richard S. ;

Mills, Gary H. ;

Minelli, Cosetta .

CRITICAL CARE, 2008, 12 (02)

[9]

BROWN GM, 1994, J PSYCHIATR NEUROSCI, V19, P345

[10]

Gastrointestinal melatonin: Localization, function, and clinical relevance [J].

Bubenik, GA .

DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (10) :2336-2348

← 1 2 3 4 5 6 7 8 9 10 →