Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

被引：234

作者：

Choi, JongYeob ^{[1
]}

Jo, MinWha ^{[2
]}

Lee, EunYoung ^{[1
]}

Choi, DooSeok ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Obstet & Gynecol,Infertil Clin, Seoul 135710, South Korea

[2] Samsung Biochem Res Inst, Clin Res Ctr, Seoul, South Korea

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 04期

关键词：

Apoptosis; autophagy; bcl-2; caspases; granulosa cell; FOLLICULAR ATRESIA; INHIBITION; IDENTIFICATION; MACROAUTOPHAGY; ENDONUCLEASE; BAFILOMYCIN; MECHANISM; NECROSIS; LC3;

D O I：

10.1016/j.fertnstert.2010.06.006

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation. (Fertil Steril (R) 2011;95:1482-6. (C)2011 by American Society for Reproductive Medicine.)

引用

页码：1482 / 1486

页数：5

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