Comparison of three different influenza vaccines in institutionalised elderly

被引：42

作者：

Baldo, V

Menegon, T

Bonello, C

Floreani, A

Trivello, R

机构：

[1] Univ Padua, Inst Hyg, Dept Environm Med & Publ Hlth, I-35151 Padua, Italy

[2] Mirano Local Hlth Unit 13, I-30035 Mirano, Venice, Italy

[3] Univ Padua, Dept Gastroenterol, I-35128 Padua, Italy

来源：

VACCINE | 2001年 / 19卷 / 25-26期

关键词：

elderly; adjuvants; influenza vaccines;

D O I：

10.1016/S0264-410X(01)00060-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The reactogenicity and the humoral immune response to three influenza vaccines were evaluated in a randomised, double-blind trial at nursing homes in north-east Italy in winter 1998-1999. Of the 285 subjects, who completed the follow-up, 93 were administered virosomal vaccine, 99 received MF59-adjuvanted vaccine and 93 had split vaccine. Ten subjects (0.3%) reported local and/or systemic reactions in the first week after immunisation. After 4 weeks, protection rates (greater than or equal to 40) were near 100% for the H1N1 and B strain and 76.0% against H3N2. The MF59-adjuvanted vaccine group had higher geometric mean titres than the other two. However, the true clinical benefit of the new adjuvanted vaccine should be further substantiated by comparative protective studies. Our results suggest that immune response to influenza vaccination in institutionalised elderly is satisfactory. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3472 / 3475

页数：4

共 13 条

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