Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness

被引：220

作者：

Lo, MS

Brazas, RM

Holtzman, MJ

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 14期

关键词：

D O I：

10.1128/JVI.79.14.9315-9319.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Respiratory syncytial virus (RSV) subverts the antiviral interferon (IFN) response, but the mechanism for this evasion was unclear. Here we show that RSV preferentially inhibits IFN-alpha/beta signaling by expression of viral NS1 and NS2. Thus, RSV infection or expression of recombinant NS1 and NS2 in epithelial host cells causes a marked decrease in Stat2 levels and the consequent downstream IFN-alpha/beta response. Similarly, NS1/NS2-deficient RSV no longer decreases Stat2 levels or IFN responsiveness. RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion.

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页码：9315 / 9319

页数：5

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