Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

被引：69

作者：

Furukawa, T

Yatsuoka, T

Youssef, EM

Abe, T

Yokoyama, T

Fukushige, S

Soeda, E

Hoshi, M

Hayashi, Y

Sunamura, M

Kobari, M

Horii, A ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Pathol, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Med, Dept Surg 1, Sendai, Miyagi 9808575, Japan

[3] Tohoku Univ, Sch Med, Dept Pediat Surg, Sendai, Miyagi 9808575, Japan

[4] Tohoku Univ, Venture Business Lab, Sendai, Miyagi 9808575, Japan

[5] RIKEN, Inst Phys & Chem Res, Gene Bank, Tsukuba, Ibaraki, Japan

来源：

CYTOGENETICS AND CELL GENETICS | 1998年 / 82卷 / 3-4期

关键词：

D O I：

10.1159/000015091

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.

引用

页码：156 / 159

页数：4

共 17 条

[1]

CHEN WH, 1982, IN VITRO CELL DEV B, V18, P24

[2]

Fukushige S, 1997, GENE CHROMOSOME CANC, V19, P161, DOI 10.1002/(SICI)1098-2264(199707)19:3<161::AID-GCC5>3.0.CO

[3]

2-W

[4] Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase [J].

Groom, LA ;

Sneddon, AA ;

Alessi, DR ;

Dowd, S ;

Keyse, SM .

EMBO JOURNAL, 1996, 15 (14) :3621-3632

[5]

Guldberg P, 1997, CANCER RES, V57, P3660

[6]

HAHN SA, 1995, CANCER RES, V55, P4670

[7]

KIJIMA H, 1994, ANTICANCER RES, V14, P2583

[8]

Kimura M, 1996, GENE CHROMOSOME CANC, V17, P88, DOI 10.1002/(SICI)1098-2264(199610)17:2<88::AID-GCC3>3.0.CO

[9]

2-X

[10]

Kimura M, 1998, CANCER RES, V58, P2456

← 1 2 →