Effect of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury

被引:65
作者
Rogatsky, GG [1 ]
Kamenir, Y [1 ]
Mayevsky, A [1 ]
机构
[1] Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel
关键词
fluid percussion brain injury; HBO2; intracranial pressure;
D O I
10.1016/j.brainres.2005.02.049
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO2) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO2 treatment has a therapeutic effect on ICP dynamics and survival following severe fluid percussion brain injury (FPBI) in rats. Changes in ICP level were analyzed every 30 min during an 8-h monitoring period following trauma and at the end of experiment (20 h). The control (A) and experimental (B) groups consisted of 7 and 4 rats, respectively. Group B was subjected to 1.5 atmospheres absolute (ATA) 100% oxygen for 60 min beginning 2 h after FPBL No significant differences in ICP were noted between groups A and B before and after HBO2 treatment until 3.5 h after trauma. At 4 h, for the first time, the difference became significant (P = 0.025; n = 11) and remained significant (P < 0.05) for all measurement points until end of monitoring, when mean ICP values reached 37.17 +/- 14.25 and 20.25 +/- 2.63 mm Hg in groups A and B, respectively. Linear approximation models showed different trends (b1 = 3.80 +/- 0.23; r(2) = 0.65, P < 0.001 and b1 = 1.56 +/- 0.25; r(2) = 0.77, P < 0.001) for groups A and B, respectively. Covariance analysis confirmed significant differences between slopes for groups A and B (F = 148.04, P < 0.001; df = 2,177), i.e., a significant difference in mean rate of ICP elevation. By the end of the experiment, 3 out of 7 rats from group A had died, but none from group B. We conclude that the application of HBO2 during the early phase of severe FPBl significantly diminished ICP elevation rate and decreased mortality level. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:131 / 136
页数:6
相关论文
共 38 条
[1]   PREDICTORS OF MORTALITY IN SEVERELY HEAD-INJURED PATIENTS WITH CIVILIAN GUNSHOT WOUNDS - A REPORT FROM THE NIH TRAUMATIC COMA DATA-BANK [J].
ALDRICH, EF ;
EISENBERG, HM ;
SAYDJARI, C ;
FOULKES, MA ;
JANE, JA ;
MARSHALL, LF ;
YOUNG, H ;
MARMAROU, A .
SURGICAL NEUROLOGY, 1992, 38 (06) :418-423
[2]  
Beaumont A, 2002, ACT NEUR S, V81, P217
[3]   Heart rate variability after acute traumatic brain injury in children [J].
Biswas, AK ;
Scott, WA ;
Sommerauer, JF ;
Luckett, PM .
CRITICAL CARE MEDICINE, 2000, 28 (12) :3907-3912
[4]  
BOUMA GJ, 1992, J NEUROTRAUM, V9, pS333
[5]   Determination of threshold levels of cerebral perfusion pressure and intracranial pressure in severe head injury by using receiver-operating characteristic curves: an observational study in 291 patients [J].
Chambers, IR ;
Treadwell, L ;
Mendelow, AD .
JOURNAL OF NEUROSURGERY, 2001, 94 (03) :412-416
[6]   Significance of intracranial pressure waveform analysis after head injury [J].
Czosnyka, M ;
Guazzo, E ;
Whitehouse, M ;
Smielewski, P ;
Czosnyka, Z ;
Kirkpatrick, P ;
Piechnik, S ;
Pickard, JD .
ACTA NEUROCHIRURGICA, 1996, 138 (05) :531-541
[7]   Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats [J].
Daugherty, WP ;
Levasseur, JE ;
Sun, D ;
Rockswold, GL ;
Bullock, MR .
JOURNAL OF NEUROSURGERY, 2004, 101 (03) :499-504
[8]  
Durmaz E, 1999, Br J Nurs, V8, P1067
[9]   Outcome of patients experiencing cardiac arrest with carbon monoxide poisoning treated with hyperbaric oxygen [J].
Hampson, NB ;
Zmaeff, JL .
ANNALS OF EMERGENCY MEDICINE, 2001, 38 (01) :36-41
[10]   RESPONSE OF CEREBROSPINAL FLUID PRESSURE TO HYPERBARIC OXYGENATION [J].
HAYAKAWA, T ;
KANAI, N ;
KURODA, R ;
YAMADA, R ;
MOGAMI, H .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1971, 34 (05) :580-+